A good read: The roots of inaction: Understanding and overcoming the obstacles to greater investment in scaling-up effective diarrhea treatment
The roots of inaction: Understanding and overcoming the obstacles to greater investment in scaling-up effective diarrhea treatment
Posted: August 20, 2012
Yale School of Medicine gets $1.8 million from Bill & Melinda Gates Foundation for oral rehydration solution ( ORS) study
New Haven, Conn. — http://media-newswire.com/release_1100879.html
To improve treatment of acute diarrhea, the Bill & Melinda Gates Foundation recently gave a two-year, $1.8 million grant to the Yale School of Medicine to design clinical trials to test the effectiveness of a major modification of oral rehydration solution ( ORS ) in the treatment of acute diarrhea in children in developing countries.
After working together on various aspects of this project for more than 15 years, a team of scientists — Dr. Henry J. Binder, professor of medicine and of cellular and molecular physiology at Yale, and his two collaborators Dr. B.S. Ramakrishna, professor of gastroenterology at Christian Medical College, Vellore, India, and Professor Graeme P. Young, head of the Flinders Centre for Cancer Prevention and Control, Flinders University, Adelaide, Australia — have proposed a modified ORS, based on the addition of a starch that reduces fluid loss.
“The development of ORS to treat diarrhea more than three decades ago has been considered one of the most important milestones in therapeutics during the last century,” says Binder. But although oral rehydration therapy has been responsible for a substantial reduction in infant mortality in the developing world, Binder says, “It is not used as much as it should be for many reasons, including the failure of mothers and caregivers to appreciate its effectiveness. Although ORS corrects dehydration, it does not reduce diarrhea.”
Since diarrhea can be caused by bacterial, viral and parasitic infections, an improvement in current therapies will have far-reaching impact, say the scientists. The primary objectives of this two-year planning grant are to establish a network of sites to collaborate in a series of clinical trials in developing countries, and to identify the most effective starch to be used in these trials.
Resistant starch – 0verview
Amylase – overview
- Amylase-Resistant Starch plus Oral Rehydration Solution for Cholera NEJM
- A Randomized Controlled Trial of Glucose versus Amylase Resistant Starch Hypo-Osmolar Oral Rehydration Solution for Adult Acute Dehydrating Diarrhea PLOS